Abstract
Abstract The incidence and distribution of the Gm allotypic markers Gm (a), (x), (g), (b) and (f) were studied in 113 Caucasian subjects who were classified on the basis of the serum titer of “natural” anti-flagellin antibodies and their response to injection with 5µg flagellin from Salmonella adelaide. There were 59 subjects with a low titer (< 100) of “natural” anti-flagellin antibodies (LNA) and of these, 43 had a low primary response (LPR, peak titer < 100) to injected flagellin; these 59 subjects were classified as “low responders.” There were 18 subjects with a high titer of “natural” antibodies (HNA, titer τ; 600) and a separate group of 36 with a high primary response (HPR, titer τ; 10,000); these 54 subjects were classified as “high responders.”. As expected in Caucasians, all subjects positive for Gm (a) were also positive for Gm (g) (64.6%) and all subjects positive for Gm (b) were also positive for Gm (f) (89.4%). The number of Gm (a,g) subjects was significantly higher in group HNA than in group LNA (P < 0.05) and significantly higher in “high responders” than in “low responders” (P < 0.05). Otherwise stated, the absence of the Gma,g gene group was associated with a lower response to flagellin. The results indicate a significant association in these subjects between the magnitude of the immune response to flagellin (indicated by antibody titers) and the Gm genotype.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
