Abstract
Abstract During sinus tachycardia following stimulation of the stellate ganglion, retrograde pressure in the sinus node artery decreased below control level. This decrease occurred independently of changes in central aortic pressure and was, furthermore, not observed in other atrial or ventricular coronary arteries. Procedures which abolished the cardiac accelerator response from adrenergic stimuli also eliminated the period of decreased retrograde pressure. These observations are considered compatible with the hypothesis of an inverse relationship between the caliber of the intranodal artery and the rate of pacemaking discharge by the sinus node.
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