RELATION OF PARENTAL HISTORY OF HYPERTENSION AND FOLLOW-UP CHANGES OF ARTERIAL STIFFNESS PARAMETERS: PP.10.397

Abstract

Objectives: Central aortic blood pressure and aortic augmentation index (AI) are independent risk factor for cardiovascular events. Cross-sectional data confirms the relationship between family history of hypertension and parameters of structure and function of the large arteries in adult offspring. The objective of the present study was to assess differences in 5-years follow - up changes in BP parameters and AI in relation to parental history of hypertension. Methods: We recruited 201 members from random families (100 parent and 101 offspring (age at baseline: 58.5 and 28.9 years). From 75 normotensive descendants 9 were with a negative family history of hypertension, 36 with one hypertensive parents and 30 with both hypertensive parents. Initially and after follow up 4.8 ± 0.4 years we recorded the radial arterial waveform using the SphygmoCor device and evaluated peripheral AI (pAI) and central AI (cAI). Significance levels of between-group comparisons of the change from baseline were assessed by a general linear model that adjusted for baseline value and post-hoc Tukey test for multiple comparison. Results: In both groups with parental history of hypertension we observed significant increase in peripheral and central systolic blood pressure (SBP) during follow-up. We found higher increase in central SBP with lesser decrease in central diastolic BP in offspring with both hypertensive parents in comparison to participants with negative family history of hypertension (pTukey < 0.05). We observed significant elevation of brachial AI only in offspring with both hypertensive parents. Changes in central AI were more pronounced in both groups with parental history of hypertension, however this increase in cAI was higher in offspring with both hypertensive parents in comparison to those without hypertension in family (6.6 vs -3.0 (%); pTukey < 0.05). Conclusions: Parental history of hypertension enhances follow-up changes in BP and augmentation index. Our findings indicate that central parameters more effectively indicate differences in changes of systolic BP and arterial wall stiffening in relation to parental history of hypertension than brachial one.