Relation of neutrophil-to-lymphocyte, platelet-to-lymphocyte ratio and CRP level with coronary artery disease severity in patients undergoing coronary angiography

Abstract

Background: coronary artery disease (CAD) is the leading cause of morbidity and mortality throughout the world. It has a complex pathophysiology, and inflammation seems to play an important role in CAD. Previous studies have shown that higher levels of inflammatory markers are associated with the severity of CAD and worse cardiovascular outcome. Although endothelial damage has been known as the triggering factor for the formation of atherosclerotic plagues, inflammatory process is responsible in the initiation and progression of the atherosclerosis. The neutrophil-to-lymphocyte ratio (NLR) and platelet- to-lymphocyte ratio (PLR) have recently been investigated as new predictors for worse cardiovascular outcome. Previous studies have shown that NLR is associated with morbidity and mortality in many cardiovascular diseases such as hypertension, heart failure, infective endocarditis, and acute coronary syndromes (ACS). Aims: The aim of this study was to explore the relation of NLR , PLR and CRP level with severity of coronary artery disease (CAD) using the Syntax score (Sxscore). Patients and Methods: This study was conducted to investigate the relationship between the severity of coronary artery disease and inflammatory markers (lymphocyte ratio, lymphocyte platelet, CRP) by sytax score in patients undergoing elective coronary angiography, the active number of 100 patients with a chronic stable was taken Coronary angiography, different markers for coronary assessment, renal function tests, INR, ECG and Echocardiography. A complete clinical evaluation was performed for each of our patients Results: Coronary lesions were evaluated by the result of camel synthesis and there was a strong relationship between NLR, PLR, CRP level, and coronary heart disease r. 526 p 0.001, r 0.317 p 0.001, r 0.699 p 0.001 However, when we divided the patient for a result Syntax The results show some difference in determining who are drafting the sentence above 21, we found a negative relationship between NLR, PLR and syntax points, while the CRP level was positively correlated at the level of the structure below 31 a significant negative correlation was found with the construct conclusion above 31. Conclusion: Our study concluded that the severity of coronary artery disease is associated with NLR, PLR, CRP levels to some extent in the patient with angina for chronic stable chest.