RELATION OF LACTOBACILLI ACIDOPHILUS TO OBESITY IN EGYPTIAN POPULATION

Abstract

Current considerations are existed about the sharing role of gut microbiota in the enhancementof obesity and allied comorbidities. This observational case-control study assessed the possiblerelation of Lactobacilli acidophilus to obesity in a sample of Egyptian population by real-timePCR in stool. The study enrolled 20 healthy slim subjects and 40 subjects who had BMI >25kg/m2. Routine laboratory analysis and identification of stool L. acidophilus by quantitative realtime PCR technique was performed for all enrolled subjects. Lactobacillus acidophilus was expressedin 21/40 (52.5%) fecal samples of obese cases and 16/20 (80%) of fecal samples of nonobeseones. In rest of samples in both groups, the expression was below the detection limit. Theresults showed that the mean lactobacilli CT was expressed in obese cases (38.89±2.57) comparedto (36.08±4.63) in non-obese cases, with high significant difference (P =0.04). Lactobacillusacidophilus was significantly lowered in obese Egyptian patients. The argument aboutsignificance correlation between imbalance in gut microbiota and obesity is one of the hot topicsin medicine.