Relation of hypertension with episodic primary headaches and chronic primary headaches in population of Rafsanjan cohort study

Movahedeh Mohammadi,Fatemeh Ayoobi,Narges Soltani,Alireza Vakilian,Carlo La Vecchia,Parvin Khalili

doi:10.1038/s41598-021-03377-7

Abstract

Headache has a variety of types, such as episodic primary headaches (EPH) and chronic primary headache (CPH) in its primary form. There is a positive correlation between these two types of headaches and hypertension (HTN), but in some works this correlation has been reported negatively. Therefore, we planned to study HTN-CPH as well as HTN-EPH correlation in our population. A sample of Rafsanjan population (10,000 individuals) entered the cohort study, as one of the Prospective Epidemiological Research Studies in Iran (PERSIAN). We compared the frequency of HTN categories in CPH and EPH cases with a normal population. Out of 9933 participants (46.6% males and 53.4% females) about 29% had EPH and 7.5% had CPH. HTN was found in 24.27% of EPH cases and 31.98% of CPH cases. HTN was also found to be associated with EPH and CPH in the crude model. Two Categories of HTN (Long controlled and uncontrolled) were not associated with EPH. On the other hand, CPH showed associations with all of the HTN categories. After included all variables and confounders, EPH and CPH had association with HTN without any considerable changes. There is strong HTN-EPH as well as HTN-CPH correlations in the studied population.

Highlights

Headache has a variety of types, such as episodic primary headaches (EPH) and chronic primary headache (CPH) in its primary form
10 percent of referrals suffering headache, to clinics of general neurology have been diagnosed with chronic daily headache (CDH), which is usually associated with poor life q uality[7]
10,000 participants were included in the baseline phase of the Rafsanjan cohort study (RCS)

Summary

Introduction

Headache has a variety of types, such as episodic primary headaches (EPH) and chronic primary headache (CPH) in its primary form. Abbreviations RCS The Rafsanjan cohort study PERSIAN Prospective epidemiological research studies in Iran EPH Episodic primary headaches CPH Chronic primary headache HTN Hypertension CVDs Cardiovascular diseases CDH Chronic daily headache CM Chronic Migraine YLDs Years lived with disability ICHD International Classification of Headache Disorders SBP Systolic blood pressure DBP Diastolic blood pressure AH Arterial hypertension TTH Tension-type headache CTTH Chronic tension type headache MOH Medication overuse headache. 10 percent of referrals suffering headache, to clinics of general neurology have been diagnosed with chronic daily headache (CDH), which is usually associated with poor life q uality[7]. Many of these patients were underdiagnosed and undertreated[8]. Women suffer from primary episodic headaches four times more often than m en[13]

Methods

Results

Discussion

Conclusion