Abstract
A dual relation exists between endocrine dysfunction<sup>1</sup>and otolaryngeal disease. First, infections of the throat and nose have an effect in producing endocrine disorders, and, second, an endocrine defect is an etiologic factor in diseases of the ear, nose and throat. The effects of systemic and focal infections on the pituitary<sup>2</sup>and the thyroid gland,<sup>3</sup>particularly, have been studied from both the histologic and the physiologic standpoint. Bacteria and inflammatory reactions have been demonstrated in each of these organs. Such investigations<sup>4</sup>show that an infection occasionally stimulates initially an increase in the activity of the affected ductless gland, which is followed by a lessening of secretion or exhaustion of the hormone. There is no difference between a systemic and a focal infection<sup>5</sup>as a cause of endocrinopathy. Also, the commoner infections are more frequently reported as etiologic factors. An infection of the tonsils, adenoids or paranasal sinuses occasionally result in
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