Relation of C-reactive protein with the components of metabolic syndrome in Asian Indian subjects

Abstract

Summary Aim The present study deals with the relation of serum high sensitive C-reactive protein (hsCRP) with different components of metabolic syndrome (MS) and its clinical relevance as a predictive marker of MS in our population. Methods : We studied 267 subjects out of which 182 were Normal Glucose Tolerant (NGT) and 85 were known diabetic patients. This group was further subdivided into (1) with MS, (2) without MS based on ATP III criteria (2001). The relation between hsCRP and components of MS was studied by univariate regression analysis. Results : We observed the prevalence of insulin resistance and metabolic syndrome to be 42% and 35.2%, respectively. Increased prevalence of central obesity, hypertension, hypertriglyceridemia and lower HDL-C was seen in subjects with MS group. hsCRP levels were significantly increased in MS group compared to without MS in NGT population. (4.72 ± 0.71 mg/dl vs. 3.06 ± 0.21 mg/dl, p Conclusions : It is seen that there is high prevalence of insulin resistance and MS in Asian Indians compared to Caucasians, accounted for by greater central obesity in Asian Indians. Elevated CRP levels are significantly associated with central obesity in individual with MS in our population. An elevated CRP level in the MS group suggests that addition of CRP to lipid evaluation provides an important tool for prediction of MS especially in Asian Indians.