Abstract

(1) An attempt was made in dogs to determine a correlation between the plasma CO2 and the gastric acidity. No such correlation could be demonstrated by the methods used. (2) The plasma CO. was lowered to 26 volumes per cent by feeding ammonium chloride. This caused no decrease in the free acidity of Pavlov pouches. Concurrent with the administration of this salt there was a great increase in the pouch secretion attributed to a coincidental water intake from thirst produced by salt ingestion. (3) The importance of evaluating the total amount of effective free acid is emphasized rather than considering only free acid “clinical units.” (4) Dehydration was quite effective in reducing the amount of pouch secretion but caused only a little change in the free acid. Dogs can be maintained for days on such a dehydration regime without apparent distress or harm.

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