Relation of arterial stiffness assessed by carotid to femoral pulse wave velocity to the extent of coronary artery disease

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Coronary artery diseases (CAD) are among the leading causes of morbidity and mortality worldwid. Carotid to femoral pulse wave velocity (cfPWV) is well validated measure of arterial stiffness and a strong independent predictor of coronary events and cardiovascular mortality among several patient groups. We examined whether cfPWV was associated with the extent of CAD in patients admitted for first acute coronary syndrome (ACS). This prospective study enrolled 275 consecutive patients < 75 years old who underwent cfPWV measurement using SphygmoCor®XCEL devise and coronary angiogram for suspected ACS at a single cardiac center, between April 2017 and March 2018. When the extent of CAD was assessed by the number of diseased vessels (diameter of stenosis ≥ 70%), there was a significant association between the latter and cfVOP ( B = 0.081, 95% confidence interval (CI) [0.019; 0.142], P = 0.010) in linear regression analysis. The multivariate logistic regression shows that cfPWV was a independent predictor of multivessel disease (odds ratio = 1.272, 95% IC [1.090; 1.483], P = 0.002). The cut-off value of cfPWV at 12.65 m/s had a sensitivity of 48.1%, specificity of 76.4%, and area under receiver operating characteristic curve of 0.638 in predicting multivessel disease. Nevertheless, cfVOP was not associated with Gensini score. CfPWV was correlated with the extent of CAD assessed by the number of diseased vessels and was a independent predictor of multivessel disease. However, it did not correlate with Gensini score.