Relation of Anemia and Hemorrhagic Shock to Experimental Ulcer Production.

Abstract

ConclusionsThe factors of post-hemorrhagic anemia and shock are evaluated in relation to their effect on the histamine-provoked ulcer in dogs. Our evidence indicates that anemia and hemodilution occurring without shock is a mild ulcer abetting factor. However, post-hemoTrhagic shock, even of relatively brief duration aids and abets the ulcer susceptibility most likely through its vasoconstrictor effect on the small blood vessels with resultant localized anemic areas in the mucosa.The combined effects of post-hemorrhagic anemia and shock on the ulcer diathesis are synergistic in that together they give a higher incidence of histamine-provoked ulcer than does either alone.