Abstract
CUSHING, in his Balfour Lecture, 1 stated that erosions and ulcers in the gastrointestinal tract are not infrequently seen in association with various cerebral lesions and after intracranial operations. He reviewed the literature covering this subject up to 1932. The generally accepted opinion is that these ulcers follow certain intracranial processes which cause a state of parasympathetic irritation or sympathetic paralysis of autonomic centers in the hypothalamus. A number of experimental studies were dedicated to this problem. 2 Mechanical or chemical stimulation of the hypothalamic region was frequently followed by hemorrhages or erosions of the gastrointestinal tract. Since Cushing's paper, the coincidence of cerebral lesions and acute peptic ulcers in man has been reported only occasionally. 3 The purpose of the present paper is to elucidate as far as possible how frequently and under what conditions acute mucosal hemorrhages and erosions of the gastrointestinal tract may be observed with and
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