Relation of abnormal DNA methylation induced by prenatal xenobiotics exposure and the development origins of disease

Abstract

Recently, Developmental Origins of Health and Disease (DOHaD) theory has come into sight gradually. The mechanism of development origins of disease has also been concerned. A number of animal experiments and epidemiological studies indicated that DNA methylation aberrance induced by prenatal xenobiotics exposure plays a vital of importance role in development origins of disease. Gestation can be divided into three semesters, which are the first trimester, the second trimester, the third trimester. The relation of DNA methylation induced by different trimesters xenobiotics exposure and the development origins of disease are different. This review summarizes the relation of abnormal DNA methylation induced by prenatal xenobiotics exposure and the development origins of disease in order to provide theory base and new direction for the prevention and new treatment method of development origins of disease. Key words: Development origins of disease; DNA methylation; DOHaD theory; Prenatal exposure; Xenobiotics