Relation of 24-Hour Urinary Aldosterone Levels with Nondipper Blood Pressure Pattern in Normotensive Individuals

Abstract

Purpose: A lot of studies conducted before have shown that there is a corelation between nondipper pattern with the left ventricular hypertrophy and diastolic dysfunction based on circadian rhythm of the blood preasure (BP). The main aim of the study is to investigate the relationship between the amount of the 24-hour urinary aldosterone and the nondipper pattern of the BP. Method: The study included both an office and ambulatory BP which were monitored in normotensive people (office BP <140/90 mmHg, and the average 24-hour BP <130/80 mmHg) in individuals who did not use any drugs and who were less than 60 years of age. A total of 85 people (54 women, with an average age of 46.2 9.1 years) were included. By continuing with the normal nutrition. All patients were subject to 24 hours measurement of the blood preasure. At the same time, urine was collected and the level of the aldosterone was being measured under the adequate conditions,and, at the end of the study, the level of adolesterone was measured from all the samples (with the diametra aldosteron kit). Results: The level of the 24hour aldosteron level turned out to be significantly high in the nondipper group according to the statistics (dipper group 8.6 (5.0, 11.6) mgr/ day, nondipper group 9.8 (7.4, 15.5) mgr/day, p1⁄40.026) (Table-1). Conclusion: The results of our study showed that the amount of the circulating aldostrone (Which is determined by measurment of 24-hour urinary aldosterone) is very high in nondippers. _ If we take into consideration that the level of aldosterone is related to the cardiac fibrosis, the high level of aldosterone in patients of nondipper group can be the cause of the heart issues. PP-019