Abstract
The relation between urinary sodium output and arterial blood-pressure was determined by perfusing isolated kidneys from normotensive rabbits with blood from normal animals. The kidneys from animals made hypertensive by the application of a clip to one renal artery were also similarly investigated. In the hypertensive animals the threshold for sodium excretion of the unclipped kidney was reset upwards, meaning that a higher perfusion pressure than normal was required for the excretion of a given quantity of sodium. The threshold of the clipped kidney (after removal of the clip) was also reset upwards to a similar degree. These observations support the predictions of a current theory of blood-pressure regulation, but the mechanism of the resetting is not known.
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