Relation between the Level of Soluble Endothelial Protein C Receptor and the Risk of Deep Venous Thrombosis in Sudanese

Abstract

Background: Deep vein thrombosis (DVT) may lead to serious complication; the pulmonary embolism; one of the most serious conditions that cause morbidity and mortality worldwide. sEPCR circulates in the plasma and has high affinity to bind protein C and activated protein C (APC). This binding interferes with the anticoagulant function of APC and results in increased risk for DVT. The aim of this study is to explore the role of sEPCR as a risk factor for DVT in Sudanese individuals. Methods: A total of 100 Sudanese DVT patients and 100 apparently healthy individuals were recruited for this study. EDTA-anticoagulated venous blood samples were collected from all participants. Plasma sEPCR levels were measured by enzyme linked immunosorbent Assay (ELISA). All results were analyzed using SPSS. Results: The plasma level of sEPCR was higher in DVT group than in healthy individuals, while male patients showed higher level when compared to females. Age correlates positively with sEPCR, whilst BMI and ethnicity showed no effect on the level of sEPCR. Individuals in the top quartiles of showed to increased risk of DVT when compared to those in the lower quartile. Conclusion: It can be concluded that elevated sEPCR level increases the risk to develop DVT in Sudanese. The level of the soluble receptor is influenced by the gender of individual more than by his/her ethnicity or body mass index. Results are also indicative of a much higher risk in those with sEPCR level more than 120 ng/ml when compared to those with lower levels.