Year-end Sale % OFF 
Abstract
treated cells, a number of differentially expressed transcripts were identified and cloned. Sequence homology search revealed and matched the identified clones to 1) a small subset of genes known to be involved in angiogenesis, e.g. platelet endothelial cell adhesion molecule 1 (PECAM-I), matrix metalloproteinase 2 (MMP2), endothelin converting enzyme 1 (ECE-I), and vascular endothelial growth factor receptor 2 (VEGFR-2); 2) a large subset of known genes with known function, but not involved in angiogenesis to date; and 3) about 5-10% of the clones were novel genes with unknown function, such as a putative G-protein coupled receptor. Thus there are clusters of related gene products, differentially regulated and involved with cholinergic, proliferative and apoptotic action. cDNA rmcroarray analysis (-48,000 elements) validated our findings Conclwon: Nicotme promotes angiogenesis through stimulation of angiogenic mechanisms partly through the cholinerglc pathway. Therapeutic modulation of nAChR may be useful in dlsorders of angiogenesis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
