Abstract
A dose of 285 krad (average) of 200-kV x-rays absorbed by isolated, frog sciatic nerves promptly inactivated impulse transmission. Blockage of neural activity in this type of nerve required 600 krad (average) of 47.5-MeV protons. Protons of this energy have a relative biological effectiveness (RBE) of 0.48 with respect to 200-kV x-rays, which have an assigned value of one. Other investigators exposed frog nerves to different types of radiation and reported inactivation doses. RBE values determined from such doses were 0.66 for 910-MeV α-particles, 0.87 for 260-kV x-rays, and 30.60 for 5.3-MeV α-particles. The RBE values to suppress neural activity depended on the linear energy transfer (LET) of the radiation particles. Radiations with high LET values had high RBE values. A plot of the logarithm of RBE vs the logarithm of LET yielded a linear relation for radiations with LET values between 1.3 and 110.0 keV/μ of tissue. Frog sciatic nerves exposed to either 200-kV x-rays or 47.5-MeV protons exhibited bioel...
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