Relation between Postmenopausal Osteoporosis and IL-17 Serum Level

Abstract

Background Osteoporosis is a bone condition that makes bones thinner and more fragile because of reduced bone density, and it puts people at risk of fractures, especially of the hip, spinal vertebrae and wrist. Aim of the Work to study possible relation between serum level of IL-17 and postmenopausal osteoporosis. Patient and Methods This was a cross sectional study that was conducted at Physical Medicine, Rheumatology and Rehabilitation department at Ain Shams University hospital including thirty postmenopausal females’ study were diagnosed as having primary post-menopausal“ type I”. Then they were further subdivided into 15 post-menopausal non-osteoporotic women with normal BMD and 15 Postmenopausal osteoporotic women with reduced bone mineral density BMD diagnosed as having Primary Post menopausal Osteoporosis According to the World Health Organization (WHO) definition of osteoporosis for post-menopausal women. The duration of the study ranged from 6-12 months. Results There was high statistically significant difference between with and without osteoporosis groups regarding DEXA Score and FRAX and IL-17 serum level. There was a significant negative correlation between IL-17 serum level and each of age and menopause duration, while there was highly significant positive correlation between FRAX and each of age and duration of menopause. ROC curve in our study showed that: IL-17 serum level can be used to diagnose osteoporosis at a cutoff level of > 80, AUC of 1.0, with 100% sensitivity, 100% specificity, 100% PPV and 100% NPV. DEXA Score can be used to diagnose osteoporosis at a cutoff level of ≤ -2.6, AUC of 1.0, with 100% sensitivity, 100% specificity, 100% PPV and 100% NPV. FRAX can be used to diagnose osteoporosis at a cutoff level of > 0.4, AUC of 0.92, with 93.33% sensitivity, 80% specificity, 82.4% PPV and 92.3% NPV. Conclusion Serum IL-17 is significantly elevated in postmenopausal osteoporosis which may indicate its role in bone-resorptive processes.