Abstract
The aim of this work was to evaluate the correlation between the serum levels of lactate dehydrogenase (LDH) and magnesium (Mg) alone or in report Ca/Mg, among patients with diagnosed malignant diseases who were admitted to the oncology department of a county hospital. Results:Among the patients in this study, 55 patients (73%) exhibited normal serum levels of Mg (normal range value = 1.60-2.3 mg/dL; mean value = 2.2 mg/dL; SD = 0.2; p = 0.02), normal values for Ca (range 9.1 -10.8 mg/100 m, mean value = 9.90, SD = 2.5, P = 0.05) and normal report Ca/Mg (range 4.5-7), following cancer therapy with good results, in the stage of remission tumor. A number of 12 patients (16%), which was discovered in onset of cancer diseases, displayed high levels of serum Mg (range =2.6-3.27 mg/dL; mean value = 2.89 mg/dL), high values of Ca, (mean value = 11.2 mg/dl), and low values of report Ca/Mg ( range = 1.7- 3.8). Six patients (8%), with bad prognostic, unfavorable cancer therapy and frequent relapses, exhibited low levels of Mg (range = 0.60-1.50 mg/dl; mean value = 1.05 mg/dL), low values of Ca (8.2-8.8 mg/dl) but high report Ca/Mg (range = 8.3-23.5). High Ca/Mg ratio was also significantly associated with high-grade cancer. The levels of serum lactic dehydrogenase (LDH) were also evaluated in patients newly diagnosed with cancer and in patients with unfavorable responses to the cancer therapy (range = 240-1330 U/L; mean value = 787 U/L; SD =1.33; p = 0.002; normal values 135-225 U/L). Conclusion: The total serum LDH, Mg and report Ca/Mg levels can be used as markers for the onset of malignant diseases and for monitoring the response to cancer therapy.
Highlights
Introduction60% of magnesium ions (1215 mg/dL) are stored in tissues and approximately 40% of magnesium ions (972 mg/ dL) contribute to intermediary metabolism
Magnesium, which is the second most abundant intracellular cation after potassium, has an essential role in the regulation of numerous cellular functions and enzymes, including ion channels, metabolic cycles and signaling pathways.Approximately 60% of magnesium ions (1215 mg/dL) are stored in tissues and approximately 40% of magnesium ions (972 mg/ dL) contribute to intermediary metabolism
The levels of serum lactic dehydrogenase (LDH) were evaluated in patients newly diagnosed with cancer and in patients with unfavorable responses to the cancer therapy (Table 1)
Summary
60% of magnesium ions (1215 mg/dL) are stored in tissues and approximately 40% of magnesium ions (972 mg/ dL) contribute to intermediary metabolism Among these ions, approximately 70% (680 mg) exist in the free form, Mg2+, whereas the other 30% of ions (292 mg/dL) are bound to proteins (especially albumin), citrate, phosphate and other complexes. The magnesium ion (Mg2+) is critical for maintaining the positional integrity of closely clustered phosphate groups. These clusters appear in numerous distinct parts of the cell nucleus and cytoplasm. The Mg2+ maintains the integrity of nucleic acids, ribosomes and proteins This ion acts as an oligo-element with role in energy catalysis [4]
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