Abstract
Type 2 diabetes (T2D) is a multi- causal disease with etiology ranging from inflammation to insulin resistance. HOMA-IR is a surrogate marker for insulin resistance in persons with T2D and can be used for diagnosing as well as follow up of insulin resistance. CRP has been widely used as a marker for inflammation of various etiologies. The relationship between the anthropometric measures BMI, waist circumference (WC) and HOMA-IR as well as between HOMA-IR and CRP were analyzed in a sample of (n=240) Haitian and African Americans with T2D. The correlations between HOMA-IR and WC, BMI and CRP were statistically significant (p<0.001). A linear regression was run with HOMA-IR as dependent variable and WC, BMI and CRP as predictor variables. WC is statistically significant in predicting HOMA-IR at a p<0.01. Data indicated that insulin resistance is negatively influenced by anthropometric measures of obesity and inflammation. Hence, its implications would be to put into use measures to reduce the BMI and WC by proper diet and exercise in this group. Further analyses needs to be conducted to assess if these simple measures can be used for follow up of patients with T2D in assessing insulin resistance. Funding of this research was provided through an NIH/NIDDK sponsored grant.
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