Relation between glucagon-like peptide 1 (GLP-1), Glucose dependent insulinotropic peptide (GIP) and HOMA index in university students

Abstract

Introduction. Diabetes mellitus is a disease which affects recently at least 415 million people around the world. Obesity is the main risk factor for the development of this disease. In the development of insulin resistance influences several factors such as carbohydrates metabolism and the secretion of GLP-1 and GIP. Objective. Correlate levels of GLP-1 and GIP with HOMA in students. Methods. A cross-sectional study was performed, we determine glucose levels using dry chemistry and GIP, GLP-1 and insulin levels were quantified by ELISA technique. A Pearson correlation between HOMA. Besides, we stratify in normal weight, overweight and obesity and we did the correlation in the three groups. Results. 78 students in total. GIP increased according to the BMI and show difference between the three groups p=0.01. The GLP-1 did not modify. HOMA index and GIP had a correlation of 0.36 with a significance p=0.002. In the other hand, HOMA index vs GLP-1 r=0.52 (p=0.001); normal weight r=0.94 (p=0.001), overweight r=0.75 (p=0.001), obesity r=0.045 (p=0.001) respectively. Conclusions. GIP and GLP-1 correlate with HOMA. The better correlation was found in GLP-1 which is higher in people with normal weight and decreases in obesity. The correlation between GIP and HOMA was low.