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Abstract
Human cytomegalovirus (HCMV), a betaherpesvirus, is ubiquitous in human population.Multiple HCMV gene products are expressed in malignant gliomas.Neural stem cells and glial cells are suscep-tible to HCMV.HCMV can induce malignant transformation and dysregulate key cellular pathways involved in host immune response, mutagenesis, cell cycle, apoptosis, and angio-genesis, and may be oncogenie in human.So, HCMV may play an active role in glioma genesis and development. Key words: Glioma; Pathogenesis; Cytomegalovirus
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