Abstract
The treatment of rats with phenobarbital caused a significant increase in hepatic microsomal content of protein and phospholipid in parallel with the induction of drug-metabolizing enzymes. In contrast, carbon tetrachloride significantly reduced microsomal protein, phospholipid, and drug-metabolizing enzyme activity. The opposing actions of these compounds were manifested mainly in the phosphatidylethanolamine, phosphatidylcholine, and lysophosphatidylcholine fractions.Actinomycin D was found to block all the effects of phenobarbital except for the increase in lysophosphatidylcholine which was inhibited only by about 50%. Actinomycin D alone significantly decreased drug-metabolizing enzyme activity and microsomal phospholipid content.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
