Abstract
During the routine screening of bloodgroup distributions of patients participating in a comprehensive drug-surveillance programme, the phenotype ss in the S antigen system was found to be in excess among patients with breast cancer. Detailed examination of two independent series of breast-cancer patients and their controls confirmed this finding, the proportions of ss phenotype for breast-cancer patients and control patients being 61 % and 46%, respectively, in one series and 56% and 41 %, respectively, in the other. The point estimate of relative risk for breast cancer in the presence of ss, derived from the two series, was 1.8, with 95% confidence limits of 1.2 and 2.7. There was also evidence to suggest that the association between ss and breast cancer may be more prominent among patients whose disease was diagnosed before the age of 50.
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