Abstract
ABSTRACTBackgroundCOVID-19 has been associated with cases of severe respiratory illness, admissions to intensive therapy units (ITUs), and high mortality rates.ObjectivesThe aim of the present study was to examine the relation between computed tomography- body composition (CT-BC) measurements, systemic inflammation, and clinical outcomes in those with COVID-19.MethodsPatients who presented to our institution between March 17 and May 1, 2020, with a positive PCR test for COVID-19 or characteristic radiological changes, were assessed for inclusion. Data collected included general demographic details, clinicopathological variables, poGPS, NLR , CT-BC measurements, and clinical outcomes including ITU admission and 30-d mortality, of those admitted.ResultsSixty-three patients met the study inclusion criteria. Forty-two patients (67%) were aged ≥70 y, 30 (47.6%) were male and 34.9% ( n = 22) had a poGPS ≥1. ITU admission was significantly associated with a high VFA ( P < 0.05). Thirty-day mortality was associated with high VFA (P < 0.05) and low SMI (P < 0.05).ConclusionsSarcopenia in the presence of obesity was associated with clinical outcomes including greater 30-d mortality.
Highlights
The WHO declared the outbreak of novel coronavirus 19 (COVID-19) a global pandemic on March 11, 2020 [1]
This is the first study to explore the relation between computed tomography- body composition (CT-BC) measurements, systemic inflammation, and outcomes in patients with COVID-19
Sarcopenia in the presence of obesity was associated with clinical outcomes including greater 30-d mortality
Summary
The WHO declared the outbreak of novel coronavirus 19 (COVID-19) a global pandemic on March 11, 2020 [1]. COVID-19 has been associated with cases of severe respiratory illness, often requiring hospitalization and in some cases admission to an intensive therapy unit (ITU), as well as high mortality rates [3]. To date, there have been no studies exploring the relation between systemic inflammation, CT-derived body composition (CT-BC) measurements, and clinical outcomes in those with COVID-19. COVID-19 has been associated with cases of severe respiratory illness, admissions to intensive therapy units (ITUs), and high mortality rates. Objectives: The aim of the present study was to examine the relation between computed tomography- body composition (CT-BC) measurements, systemic inflammation, and clinical outcomes in those with COVID-19.
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