Abstract
Microalbuminuria is an independent predictor for cardiovascular disease in diabetes mellitus.1 In addition, there is evidence that microalbuminuria increases cardiovascular risk in nondiabetic populations.2 However, in almost all studies microalbuminuria has been used as a dichotomous variable and little is known about the precise relation between urinary albumin excretion (UAE) and cardiovascular disease. If UAE can be considered as a continuous variable, this could have important implications for individual cardiovascular risk assessment. We evaluated the association between the level of UAE, including levels within normal ranges, and ischemic electrocardiographic (ECG) abnormalities in a general nondiabetic population. To establish the value of UAE as an independent risk factor, we also examined the relation between UAE and these ECG abnormalities, taking conventional cardiovascular risk factors into account.
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