Abstract
Objective: The manuscript investigates the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population. Methods: We designed a case-control study involving 340 normal glucose tolerant (NGT) subjects and 340 type 2 diabetes patients. Three SNPs (rs182052, rs1501299, and rs7627128) were genotyped by TaqMan methods. Results: We found that rs7627128, rs1501299 and rs182052 were significantly associated with T2DM. Haplotypes analysis indicated that the frequency of the haplotypes A-A-T was frequent in T2DM patients (OR = 2.10; 95%CI: 1.44–2.90; p < 0.001), but G-A-T was more frequent in the control group than in the T2DM group (OR = 0.66; 95%CI: 0.54–0.81; p < 0.001). Conclusion: The ADIPOQ genetic polymorphisms were associated with type 2 diabetes in a Chinese population.
Highlights
The pathogenesis of type 2 diabetes mellitus (T2DM) remains unclear
Adiponectin is a product of the ADIPOQ gene, which is located on human chromosome 3q27, where a region composed of three exons that span 17 Kb, identified as a susceptibility locus for metabolic syndrome and T2DM, has been reported [9,10]
We found that the ADIPOQ gene rs1501299, rs182052 and rs7627128 polymorphisms were significantly associated with T2DM in a Chinese population
Summary
The pathogenesis of type 2 diabetes mellitus (T2DM) remains unclear. previous studies suggested that T2DM is a complex disease resulting from the interaction between genetic polymorphisms and environmental factors [1]. Several genes have been identified as susceptible genes for T2DM, including the C5L2 gene [2], CYP2J2 gene [3] and CCR5 gene [4,5]. Adipose tissue was considered to play an important role in the pathogenesis of diabetes, as well as obesity by secreting a variety of secretory proteins [6]. Adiponectin is a product of the ADIPOQ gene, which is located on human chromosome 3q27, where a region composed of three exons that span 17 Kb, identified as a susceptibility locus for metabolic syndrome and T2DM, has been reported [9,10]. T2DM is a complex heterogeneous group of metabolic disorders, including hyperglycemia and impaired insulin action and/or insulin secretion, and a detailed etiology underlying
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