Abstract
Neuronal activity at the VIM nucleus of the thalamus was recorded in Essential Tremor (ET) patients during implantation of deep-brain stimulation (DBS) electrodes and compared with surface-EMG (sEMG) taken both during implantation and at later outpatient sessions at University of Illinois Hospital, Chicago. The goal of these studies was to investigate if it is possible to use sEMG signals for predicting onset of tremor and consequently whether predictive EMG-control of DBS in ET patients does or does not contradict predictive features of neuronal activity in the brain. For this purpose, we examined spike-rate and local field potentials (LFP) at and in the vicinity of VIM. Specifically, we compared spike-rate, LFP and sEMG recorded before versus after applying short DBS pulse-trains during implantation surgery, as well as sEMG recorded from limbs or neck of the patients. Out of 4 ET patients involved in the tests, we have implant-session data for 3 patients. Three patients had follow-up EMG testing.
Highlights
Neuronal activity at the VIM nucleus of the thalamus was recorded in Essential Tremor (ET) patients during implantation of deep-brain stimulation (DBS) electrodes and compared with surface-EMG taken both during implantation and at later outpatient sessions at University of Illinois Hospital, Chicago
Results show that spike rate dropped from 15.94 spikes/ s to 0.97 at the end of a DBS pulse-train in patient ET1, from 45.44 to 34.78 in patient ET3 and from 22.9 to 0.26 in Patient ET 4, for periods on 12-40 seconds (Fig 1-left)
* Correspondence: graupe@uic.edu 1Dept. of Electrical and Computer Engineering, University of Illinois, Chicago, IL, USA Full list of author information is available at the end of the article stimuli, is based on EMG wavelets and entropy parameters derived from the signal, rather than on EMG power [1]
Summary
Neuronal activity at the VIM nucleus of the thalamus was recorded in Essential Tremor (ET) patients during implantation of deep-brain stimulation (DBS) electrodes and compared with surface-EMG (sEMG) taken both during implantation and at later outpatient sessions at University of Illinois Hospital, Chicago. Relating thalamic neuronal activity and EMG for validating predictive control of deep-brain stimulation in Essential Tremor patients Daniel Graupe1,2*, Ishita Basu1, Daniela Tuninetti1, Konstantin V Slavin3
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