Related risk factors of neurological deterioration in patients with acute cerebral infarction

Abstract

[Objective]To investigate the related risk factors of neurological deterioration in patients with acute cerebral infarction.[Methods]One hundred and eighty-five patients with acute cerebral infarction,admitted to our hospital from February 2005 to January 2010,were chosen in our study;these patients were divided into progress group and control group according to the scores of modified Edinburgh-Scandinavia stroke scale (MESSS,neurologic impairment):the gender,age,systolic blood pressure,diastolic blood pressure,MESSS scores,levels of tumor necrosis factor α(TNF-α) and interleukin 1 β,(1L-1 β) and other 20 related factors were collected and compared between the 2 groups;related risk factors affected the prognosis of patients with acute cerebral infarction were selected through univariate analysis and multivariate analysis of the above 27 factors.[Results] Univariate analysis showed that MESSS scores,histories of high-cholesterol and diabetes,and levels of blood sugar,ibrinogen,serum ferritin and glycated hemoglobin,and levels of C-reaction protein (CRP),total cholesterol (TC） and low density lipoprotein (LDL),and levels of soluble intercellular adhesion molecule (SICAM-1) and TNF-α in the progress group had statistically significant differences with those in the control group (P＜0.05).Multivariate regression analysis showed that levels of LDL,CRP and SICAM-I,and high cholesterol history were the independent risk factors that influenced the prognosis of acute cerebral infarction.[Conclusion] Levels of LDL,CRP and SICAM-1,and high cholesterol history are the independent risk factors influencing the prognosis of acute cerebral infarction,and these risk factors can be used to judge the treatment effect and as index ofacute cerebral infarction. Key words: Cerebral infarction; Risk factor, Neurologic impairment