Related risk factors analysis of middles-aged type 2 diabetes patients with benign prostatic hyperplasia

Abstract

Objective To investigate the influencing factors of middle-aged patients with benign prostatic hyperplasia and type 2 diabetes(T2DM). Methods One hundred male patients diagnosed as T2DM clinically aged from 40 to 60 were divided into two groups according to the benign prostatic hyperplasia, with 60 cases in BPH group, and 40 cases in non- BPH group. Physical indexes such as height and weight were measured in all patients, and body mass index was calculated. Follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), total testosterone(T), prolactin (PRL), sex hormone binding globulin(SHBG), blood lipid profile and indexes of glucose metabolism were measured in all patients, free testosterone(FT), HOMA-IR(CP), pancreatic β cell function were calculated with formula, and made a comparison of their clinical data. Results Compared with non- BPH group, the BPH group had significant differences in age(50.33±4.46 vs 47.53±6.94, P<0.05), glycosylated hemoglobin[(8.91±1.98)% vs (7.95±1.17)%, P<0.05)], HOMA-IR(CP)(3.26±0.82 vs 2.86±0.61, P<0.05), FT[(0.31±0.12)nmol/L vs (0.40±0.16)nmol/L, P<0.05)], E2/FT(106.55±58.22 vs 72.52±33.82, P<0.05). The volume of prostate was positively correlated with E2, E2/FT, HbA1c, HOMA-IR, and negatively correlated with FI(P<0.05). Conclusions In middle-aged type 2 diabetic man, the disordered sex hormones, high blood glucose and obesity can promote the progress of BPH. Key words: Type 2 diabetes; Male; Benign prostatic; Testosterone; Insulin resistance