Related factors of thyroid-associated ophthalmopathy in patents with Graves' disease after 131I treatment

Abstract

Objective To analysis the related factors of thyroid-associated ophthalmopathy(TAO) in patients with Graves' disease after 131I treatment.Methods Five hundred and sixty two patients with Graves'disease were followed up after 131I treatment,included 243 cases with TAO and 319 cases without TAO.Logistic multivariate regression analysis was used to analyse the data of the improvement of the TAO,stablity and progression.Results Of the patients without TAO,10 new cases of TAO were diagnosed (3.13％).Of the paitents with TAO,134 (55.14％) had experienced improvment,99 (40.74％) cases with stable disease and 10 (4.12％) cases with progressed disease.The progression rate were no difference between the part of patients with and without TAO (x2=0.576,P＞0.05),and were difference between simple and invasive prominent eyes groups (x2=11.893,P＜0.05).The rate of improvement between simple and invasive prominent eyes groups also had statistical significance (x2=10.621,P＜0.05).By Logistic analysis,the history of smoking,low levels of TSH,severity of TAO,and dysfunction of thyroid were risk factors of deterioration of TAO,treatment with glucocorticoid is protection factors.Conclusion 131I therapy had no obviously influence between Graves'disease with and without TAO,and early controling the risk factors and treatment with glucocorticoid could prevent aggravation of TAO. Key words: Graves disease; Iodine radioisotopes; Graves ophthalmopathy; Factors analysis, statistical