Abstract
BackgroundThe main causes of intracerebral hemorrhage differ between young adults and older adults. Data regarding potential targets for early intervention in young adult patients with intracerebral hemorrhage are lacking.MethodsWe retrospectively analysed data for 196 young adult patients with intracerebral hemorrhage who were admitted to Tianjin Huanhu Hospital and died within 30 days of admission between June 2005 and June 2015. The Kaplan–Meier method was used to calculate survival rate, and the log-rank test was used to determine survival rate significance. A Cox proportional hazards regression model was used for univariate and multivariate analyses.ResultsUnivariate analysis revealed a statistically significant association of age, disturbance of consciousness, National Institutes of Health Stroke Scale and Glasgow Coma Scale scores, seizure occurrence, infratentorial hemorrhage, intraventricular extension, hernia, glucose level, white blood cell count, albumin level, creatinine level, uric acid level, and surgical treatment with early mortality (P<0.05). However, multivariate regression analysis revealed that only infratentorial hemorrhage (P=0.003) and intraventricular extension (P=0.003) were significant risk factors for early mortality.ConclusionsOur results suggest that young adult patients who exhibit infratentorial hemorrhage and intraventricular extension in the early stages of intracerebral hemorrhage onset exhibit an increased risk of early mortality.
Highlights
Intracerebral hemorrhage (ICH) refers to primary nontraumatic hemorrhage of the cerebral parenchyma
The included patients were classified into three groups according to their systolic (SBP) and diastolic blood pressure (DBP) values: SBP < 140 mmHg, 28 patients (14.29%); 140 mmHg ≤ BP < 180 mmHg, 58 patients (29.59%); SBP ≥ 180 mmHg, 110 patients (56.12%); DBP < 90 mmHg, 52 patients (26.53%); 90 mmHg ≤ DBP < 110 mmHg,71 patients (36.22%); and DBP ≥ 110 mmHg, 73 patients (37.24%)
The results of the present study revealed that intraventricular extension was an independent risk factor for early mortality in young adult patients with ICH
Summary
Intracerebral hemorrhage (ICH) refers to primary nontraumatic hemorrhage of the cerebral parenchyma. The incidence rate of ICH is second only to that of cerebral ischemic stroke. The main causes of ICH differ between young adults and older adults. The main causes of ICH include hypertension, type 2 diabetes mellitus, hypertensive arteriopathy, cerebral amyloid angiopathy, and medication. Data regarding potential targets for early intervention in young adult patients with ICH are still lacking. We conducted the present study to analyse risk factors associated with early mortality in young adult patients with ICH, with the goal of elucidating targets for decreasing mortality and disability rates and improving clinical outcomes. The main causes of intracerebral hemorrhage differ between young adults and older adults. Data regarding potential targets for early intervention in young adult patients with intracerebral hemorrhage are lacking
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