Related factors of cough variant asthma turning into typical asthma in children

Abstract

Objective To investigate the related factors of cough variant asthma (CVA) turning into typical asthma (CA) in children. Methods A total of 175 children with CVA in Lucheng Hospital of Traditional Chinese Medicine from August 2013 to July 2016 were selected. The general conditions (age, sex, clinical symptoms, duration of cough, course of disease), related risk factors (host factors, environmental factors) and corresponding treatment were recorded. After 6 months of treatment, the conversion of CVA to CA, and the related risk factors were analyzed. Results After treatment, 44 cases of the 175 children with CVA converted to CA, while the remaining 131 children did not convert to CA. There was no significant relationship between age, sex, course of disease and the conversion of CVA to CA (P>0.05). Family asthma history, children’s atopic constitution, treatment compliance and respiratory tract infection were the influencing factors of the conversion of CVA to CA(P 0.05). Indoor dust, passive smoking and new house decoration were the influencing factors of the conversion of CVA to CA (P 0.05). Logistic multivariate regression analysis showed that family history of asthma, atopic constitution, respiratory infection and poor treatment compliance were important risk factors of the conversion of CVA to CA (P<0.05). Conclusions Family history of asthma, atopic constitution, respiratory tract infection and poor treatment compliance may be related risk factors of the conversion of CVA to CA. Corresponding interventions against these risk factors can avoid the disease progressing to typical asthma, and have positive significance for improving clinical efficacy and prognosis. Key words: Cough variant asthma; Typical asthma; Risk factors