Related factors of co-occurring mood disorders among heroin-dependent patients

Abstract

Objective To explore related factors of co-occurring mood disorders among heroindependent patients. Methods A cross-sectional study was conducted.Subjects were 1002 heroindependent patients who were consecutively admitted into three drug rehabilitation institutes in Hunan Province.A questionnaire was developed to get demographic and drug use-related information of the subjects.The Structured Clinical Interview for DSM-Ⅳ-TR AxisⅠDisorders-Patient Edition (SCIDI/P) was used for the lifetime DSM-ⅣaxisⅠdiagnoses.According to the co-occurrence of mood disorders,the heroin-dependent subjects were assigned into two groups: one group contained individuals with mood disorders in their lifetimes (n=191),and the other contained individuals without mood disorders (n=881).Bivariate and multi-variate logistic regression were used to detect related factors of co-occurring mood disorders among the heroin-dependent patients. Results By bivariate analyses,the factors related to co-occurring mood disorders were being divorced or widowed (OR=1.65,95% CI=1.06-2.59),childhood adversity (OR=1.58,95% CI=1.11-2.25),to alleviate depression or be worry at the first time of using heroin (OR=2.41,95% CI=1.48-3.92),feeling uncomfortable from the first time of heroin use (OR=1.61,95% CI=1.16-2.24),times of receiving compulsive rehabilitation (3-5 times,OR=2.33,95% CI=1.02-5.28;≥6 times,OR=3.17,95% CI=1.27-7.88),having chronic physical diseases (OR=1.90,95% CI=1.36-2.66),family history of DSM-ⅣaxisⅠmental disorders (OR=2.03,95% CI=1.17-3.55),having lifetime diagnoses of other substance use disorders (OR=2.19,95% CI=1.55-3.09),anxiety disorders (OR=2.48,95% CI=1.65-3.73),and somatoform disorders (OR=2.10,95% CI=1.17-3.77).By multivariate analyses,the factors finally entered into the logistic regression models were to alleviate depression or worry at the first time use of heroin (OR=2.48,95% CI=1.47-4.20),feeling uncomfortable from the first time use of heroin (OR=1.61,95% CI=1.15-2.26),having chronic physical diseases (OR=1.92,95% CI=1.34-2.74),having lifetime diagnoses of other substance use disorders (OR=2.19,95% CI=1.55-3.09),anxiety disorders (OR=2.48,95% CI=1.65-3.73),and somatoform disorders (OR=4.48,95% CI=2.04-9.84). Conclusions Adverse emotions,physical diseases,other psychiatric and substance use disorders may predict the co-occurrence of mood disorders in heroin-dependent patients.These findings could have some implications for future researches and clinical interventions. Key words: Heroin dependence; Mood disorders; Co-occurring disorders; Related factor