Related factors and prognosis of periventricular hemorrhage-intraventricular hemorrhage in preterm infants

Abstract

Objective To investigate the coagulation function, the related factors and prognosis of preterm infants with periventricular hemorrhage-intraventricular hemorrhage(PVH-IVH). Methods Eighty-one preterm infants with PVH-IVH and 81 infants with non-PVH-IVH as a control were enrolled in the study.The changes in activated thromboplastin time(PT), activated partial thromboplastin time(APTT), Fibrinogen and D-dimer were determined by enzyme-linked immunosorbent assay.Clinical factors which were related to PVH-IVH in infants were analyzed with statistical analysis and prognosis was assessed with neonatal behavioral neurological assessment (NBNA). Results The average of gestational age in PVH-IVH group was(30.9±1.79)weeks, in control group were(31.36±1.39)weeks, and there was significant difference between the 2 groups(F=6.52, P=0.012). There were significant differences in APTT, and D-dimer between PVH-IVH and non-PVH-IVH infants(all P<0.05). Multivariate Logistic regression analysis showed that the related factors included gestational age, neonatal respiratory distress syndrome(NRDS), hyperoxia, and mechanical ventilation(OR=3.98, 1.72, 2.99, 5.65, all P<0.05). The NBNA scores of the 2 groups were also significantly different(t=9.16, P<0.05). Conclusions The occurrence of PVH-IVH is very complex resulted from gestational age, NRDS, hyperoxia, mechanical ventilation and other factors.In order to avoid the occurrence of intracranial hemorrhage and improve the life quality of preterm infants, the NRDS was prevented as far as possible, coagulation abnormalities were managed positively and the mechanical ventilation was shortened. Key words: Periventricular hemorrhage-intraventricular hemorrhage; Coagulation function; Related factors; Neonatal behavioral neurological assessment scores