Abstract
To explore the prevalence and related factors of essential tremor (ET) in permanent residents of Hetian, Xinjiang. By cluster random sampling, the local residents ( ≥ 10 years) at the age of 45 years and above in Hetian, Xinjiang received an epidemiological survey covering 1 city and 7 counties. Hetian City, Yutian County, Moyu County and Luopu County were randomly selected. According to the diagnostic standard of ET, the ET patients were screened face-to-face to understand the factors related to the pathogenesis of ET. And for this case control study, a ratio of 1: 1 was used to randomly select healthy subjects without ET as the control group. Both groups were matched with regards to gender, nationality and age ( ± 2 yr). The EpiData 3.1 software was employed. And the data were independently entered to analyze the prevalence of ET in various age groups. The statistical software SPSS 19.0 was used for single factor analysis and multivariate conditional Logistic regression analysis. P < 0.05 was statistically significant. A total of 5 932 patients responded to the questionnaire and there were 216 cases of ET patients. The total prevalence rate of ET was 3.64% in those aged over 45 years old and the prevalence rate over 45 years of age was 3.76% for males and 3.52% for females. The prevalence of 45-54, 55-64, 65-74 and ≥ 75-year old were 3.08%, 3.72%, 4.08% and 4.31% respectively. Multivariate conditional Logistic regression analysis showed: the pesticide exposure history (B = 2.664, χ(2) = 86.773, P < 0.05, OR = 14.347, 95% CI 8.192-25.127) and family history (B = 3.191, χ(2) = 61.430, P < 0.05, OR = 24.303, 95%CI 10.943-53.972) were associated with increased risk of ET while occupation, education, sports, social activities, drinking tea, eating habits and the incidence of ET had no obvious correlation. ET has a prevalence rate of 3.64% in Hetian, Xinjiang, And it has a rising trend with advancing age. The pathogenesis of ET is probably correlated with age, pesticide exposure history and family history. Thus theoretic rationales may be provided for early prevention and treatment of ET in the area.
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