Related factor analysis for persistent severe hypocalcemia after parathyroidectomy in secondary hyperparathyroidism patients

Abstract

Retrospective analysis of clinical data was conducted in the patients with secondary hyperparathyroidism(SHPT)undergone parathyroidectomy(PTX)in our department from September 2015 to September 2016. Uni- and multivariate analyses were conducted to define independent influencing factors for persistent severe hypocalcemia. The results showed that 27 cases(31%)suffered from persistent severe hypocalcemia in a total of 87 patients. Univariate analysis revealed that age, weight, hospitalization time after operation, the year of increased serum creatinine, preoperative alkaline phosphatase(ALP), preoperative intact parathyroid hormone(iPTH), preoperative albumin, postoperative 1 d serum calcium and phosphorus level, renal hypertension, and degeneration of bone were risk factors of persistent severe hypocalcemia. Multivariate analysis revealed that the year of increased serum creatinine, preoperative ALP, and preoperative albumin were the independent influence factors for persistent severe hypocalcemia. (Chin J Endocrinol Metab, 2018, 34: 57-60) Key words: Persistent severe hypocalcemia; Secondary hyperparathyroidism; Parathyroidectomy