Relapsing Superficial Thrombophlebitis Attacks Following Inactive COVID-19 Vaccination (Sinovac/CoronaVac) in aPreviously Inactive Patient with Behçet Disease

Abstract

To report a case with relapsing superficial thrombophlebitis attacks following two doses of inactive coronavirus disease-2019 (COVID-19) vaccination (Sinovac/CoronaVac) in a previously inactive young patient with Behçet disease. A 26-year-old patient with recurrent oral aphthae, erythema nodosum, and positive pathergy test was diagnosed with Behçet disease. The patient had 2 doses of SARS-Cov-2 vaccine (Sinovac/CoronaVac-China) vaccination for COVID-19 repeated each 4-week interval and he developed an attack of superficial thrombophlebitis of the vena saphena magna, proved by venous doppler ultrasound. He was treated with 4-week course of methylprednisolone (0.5 mg/kg/day) plus acetylsalicylic acid (100 mg/day) in addition to the current immunosuppressive management. A prompt and sustained response was obtained with repeated Remicade® (infliximab) infusions (5-mg/kg; weeks 0, 2, 6 and 10).