Abstract
The central nervous system (CNS) involvement in progressive systemic sclerosis (PSS) is rare, which has been considered to be either uncommon or a secondary consequence of hypertension, uremia, pulmonary dysfunction and steroid treatment (1-3). White matter hyper intensities (WMHI) on MRI were more common in patients with PSS than in the control group, which might be asymptomatic and inadequate of the disease duration (2, 3). We report a unique case of PSS where WMHI have arisen in both the middle cerebellar peduncles and left temporal lobe, and made rapid progress into tumefactive WMHI in the subcortices of both precentral gyri. To the best of our knowledge, tumefactive form of PSS has not been reported.
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