Abstract
Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. There is not a good relationship between the dose of the carbamazepine and their effects in humans, but the effects of this drug have been well correlated with its plasma levels. To measure the correlation between plasma and saliva levels of carbamazepine in children with epilepsy. Saliva and plasma levels of carbamazepine were measured by using instrumental planar chromatography in 11 epileptic children aged 8 to 15 years treated with the drug for at least six months. The mean saliva/plasma ratio was 0.18+/-0.05 and the mean of carbamazepine concentration in saliva, expressed as a percentage of concentrations in plasma, was 17.97+/-5.40. There was a poor linear correlation (r=0.37) between the concentrations of carbamazepine in both fluids. In this group of epileptic children the correlation between saliva and plasma carbamazepine levels was weak.
Highlights
Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect
Los sujetos incluidos en este estudio (n =11) fueron pacientes que recibían carbamazepina como medicamento para la epilepsia, que se atendían en el Policlínico de Neurología del Hospital Las Higueras de Talcahuano, Chile, que tenían indicado el control de los niveles plasmáticos de este fármaco y que aceptaron participar, previo consentimiento informado de sus padres
Sería deseable aumentar el número de pacientes en el futuro para poder así obtener una conclusión definitiva respecto a la correlación entre los niveles de carbamazepina en saliva y plasma, y concluir si la determinación de la concentración de este medicamento en saliva es un estimador confiable de sus niveles en plasma
Summary
Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. Los sujetos incluidos en este estudio (n =11) fueron pacientes que recibían carbamazepina como medicamento para la epilepsia, que se atendían en el Policlínico de Neurología del Hospital Las Higueras de Talcahuano, Chile, que tenían indicado el control de los niveles plasmáticos de este fármaco y que aceptaron participar, previo consentimiento informado de sus padres.
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