Abstract
<p>Angiotensin-converting enzyme (ACE) activity in serum and insertion/deletion (I/D) polymorphism have been associated to cardiovascular disease in several studies. Objective. To find a relationship between ACE activity and I/D polymorphism in the enzyme gene in patients with coronary obstruction revealed by angiography. Materials and methods. Sample comprised patients attending a hemodynamics center in Quindío in need of a coronary angiography. ACE activity was measured by electrophotometry and the I/D genotype determined by polymerase chain reaction. Results. 542 patients were divided into two groups: individuals with coronary obstruction higher than or equal to 50% (OC≥50) and individuals with coronary obstruction less than 50% (CO&lt;50%). Serum ACE activity in the global population was higher in individuals with DD polymorphism, followed by ID and II with significant differences. A similar pattern was shown in both study groups but without significant differences, although enzyme activity was always higher in individuals with OC≥50% compared with patients with OC&lt;50%. ID genotype was the most frequent in both groups. No differences were found in allele and genotype frequencies in the study groups. Conclusions. Significant differences in ACE activity were found<br />according to genotype. Our study did not find any relationship between ACE activity, I/D polymorphisms and coronary obstruction.</p><p><br />Key words: angiotensin-converting enzyme, coronary obstruction, ID polymorphism, angiotensin.</p>
Highlights
Relação entre enzima conversora de angiotensina, polimorfismo I/D e obstrução coronária numa população de Quindío, Colômbia
Para ambos os grupos de estudo o padrão foi semelhante, mas sem diferenças significativas, embora a atividade da enzima foi sempre maior em indivíduos com obstrução coronária ≥50% (OC≥50)% em comparação com pacientes com OC
Insertion/deletion polymorphism in the angiotensinconverting enzyme gene affects heart weight
Summary
Se incluyeron en el estudio pacientes de ambos sexos admitidos de manera secuencial en el Centro de Hemodinámia del Quindío entre el 2008 y el 2009, con necesidad clínica de una angiografía coronaria, e historia de isquemia cardiaca y al menos un evento cardiovascular mayor. No se incluyeron pacientes embarazadas, o pacientes con disbetalipoproteinemia, hiperlipidemia, hipertensión no controlada, daño renal, o síndrome nefrótico idiopático. Todos los pacientes fueron incluidos prospectivamente, antes de la angiografía firmaron un consentimiento informado y llenaron una encuesta para obtener los datos demográficos básicos (edad, sexo, dieta, los antecedentes médicos personales y familiares y otros factores de riesgo cardiovascular). El estudio fue aprobado por el comité de bioética de la Universidad del Quindío
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