Abstract
Relationship between diet and serum levels of lipids and lipoproteins in adults with different apolipoprotein E genotypes. Objective. To find a possible relationship between: usual diet, lipid profile and ApoE genotypes. Materials and methods. Assessment of lipid profile, nutritional status and body fat percentage was conducted on 150 lecturers of the Pontificia Universidad Javeriana. Other variables were: age, gender, polymorphism of the ApoE gen, health status and food consumption. Results. 76 subjects were normolipidemic (NL) and 74 were hyperlipidemic (HL). Total cholesterol (TC), LDLc and triglycerid (TG) average values (mg/dl) were 164.68‐22.57; 91.82‐23.39 and 89.45‐31.13 respectively for the NL group, and 223.67‐20.25; 145.25‐19.99 and 198.74‐49.95 respectively for the HL group. Average age was 38.4‐8.4 for NL and 39.7‐8.2 for HL; gender distribution was of 31 men and 45 women in NL, and 50 men and 24 women in the HL group. ApoE genotype frequency was similar to that reported in other populations around the world. The evaluation of energy and nutrient consumption revealed an intake higher than the overall recommendation for all the nutrients, except cholesterol in HL women. Conclusion. When correlating consumption, lipid profile and genotypes, no significant differences were found, neither in lipid nor lipoprotein levels. However, a tendency was observed in the 4/3 genotype to be prone to higher cholesterol levels compared to other genotypes, especially in the HL group.
Highlights
Relação da dieta com os níveis plasmáticos de lipídeos e lipoproteínas em indivíduos adultos com diferentes genótipos do gene da apolipoproteína E
Las características generales en cuanto a los antecedentes de salud tanto personales como familiares, hábitos de vida saludables y hábitos alimentarios presentaron un comportamiento similar entre los grupos de normolipidémicos e hiperlipidémicos
Adicionalmente, se confirma que el efecto de los genotipos de la ApoE se nota más claramente en las situaciones patológicas que en las personas con condiciones normales de perfil lipídico
Summary
UNIVERSITAS SCIENTIARUM Disponible en línea en: www.javeriana.edu.co/universitas_scientiarum 2009, Vol 14 N° x, xx-xx. Establecer la posible relación entre dieta habitual, perfil lipídico y los genotipos de ApoE. Participaron 150 profesores de la Pontificia Universidad Javeriana, se evaluó perfil lipídico, estado nutricional y porcentaje de grasa corporal. Otras variables: edad, género, polimorfismo del gen ApoE, estado de salud y consumo de alimentos. Los valores promedio de colesterol total (CT), LDLc y triglicéridos (TG) (mg/dl) fueron de 164,68 ± 22,57; 91,82 ± 23,39 y 89,45 ± 31,13 para el grupo NL y de 223,67 ± 20,25; 145,25 ± 19,99 y 198,74 ± 49,95 para el grupo HL. La evaluación del consumo de energía y nutrientes mostró una ingesta mayor que la recomendación para todos los nutrientes en la población en general, excepto para el consumo de colesterol en mujeres hiperlipidémicas. Palabras clave: apolipoproteína E, consumo de alimentos, estado nutricional, genotipo, perfil lipídico, polimorfismo
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