Abstract
A documented synthetic method, even a sophisticated one, is not always inornate and viable for synthesizing novel compounds due to the obscured compatibility with the reactivity of specific functional groups. With a unique indolo[1,2-c]quinazoline framework, hinckdentine A has provoked renewed interest in the scientific community for the opportunity to develop new synthetic methods and strategies. Four groups have completed the total synthesis of hinckdentine A with distinct approaches enabled by improving the Pinacol-type rearrangement, base-promoted stereospecific alkyl migration, the intramolecular Heck reaction, the aryne-initiated cascade reaction, and electrolytic radical cyclization. The tentative biogenesis of hinckdentine A has been proposed to inspire future development of efficient synthesis and biosynthetic study.
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