Abstract
Experimental pipestem fibrosis of the liver developed more frequently (69.2%) in mice submitted to repeated infections with Schistosoma mansoni, than with single infection (11.1%). The counting of eggs in the liver revealed no significant differences between the two experimental groups. Although the reason why multiple infections favor the development of pipestem fibrosis has not been elucidated, the data obtained represent an experimental support to clinico-epidemiological claims that repeated infections play a role in pathogenesis of hepatosplenic schistosomiasis
Highlights
Experimental pipestem fibrosis of the liver developed more frequently (69.2%) in mice submitted to repeated infections with Schistosoma mansoni, than with single infection (11.1%)
The counting of eggs in the liver revealed no significant differences between the two experimental groups
Alguns dados da patologia experimental aparentemente apoiam esta tese, pois o desenvolvimento da chamada fibrose pipestem no chimpanzé só foi obtida com infecções múltiplas[16]
Summary
Experimental pipestem fibrosis of the liver developed more frequently (69.2%) in mice submitted to repeated infections with Schistosoma mansoni, than with single infection (11.1%). A base desta suspeita deriva da observação de que os indivíduos infectados que migram para fora da área endêmica não mais desenvolvem a forma hepato-esplênica[5 11 12]. Alguns dados da patologia experimental aparentemente apoiam esta tese, pois o desenvolvimento da chamada fibrose pipestem no chimpanzé só foi obtida com infecções múltiplas[16].
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