Abstract
Two new 26-membered macrolides, reidispongiolide A ( 1) and B ( 2), have been isolated from the New Caledonian marine sponge Redispongia coerulea n.gen.n.sp. Lévi and Lévi and their structures elucidated. They are related to sphinxolides previously isolated from an unknown nudibranch and later from the sponge Neosiphonia superstes. 1 and 2 co-occurr with sphinxolide B ( 4) and D ( 3). These macrolides exhibited potent cytotoxicity against various human carcinoma cells.
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