Abstract
Recent development in the clinical application of cell therapy is potentially useful for treatment of osteonecrosis of the femoral head (ONFH). Rehabilitation is essential to improve the hip joint function and activity of patients. Rehabilitation program after cell therapy for ONFH treatment and other regenerative medicine fields is known. This narrative review aimed to assess the actual state of the rehabilitation program after cell therapy for ONFH. Seventeen publications met the inclusion criteria and were included in the review. This review focused on weight bearing, muscle strength exercise, range of motion exercise, and physical activity. Considerable information is available on weight bearing, but data on muscle strength exercise, range of motion exercise, and physical activity are insufficient. The initial timing of weight bearing may influence the result. Biomechanical, biophysical, physiological, and radiological knowledge are essential in designing the protocol. Moreover, knowledge on cell biology is required to promote the effect of cell therapy.
Highlights
Cell therapy is a promising treatment for refractory diseases, such as idiopathic osteonecrosis of the femoral head (ONFH), which is difficult to treat [1]
The rehabilitation program for this treatment still requires further development. This narrative review aimed to assess the actual state of the rehabilitation program after cell therapy for ONFH
Publications were excluded based on the following criteria: (1) review article; (2) clinical trials on other diseases; (3) animal subjects; (4) patients
Summary
Cell therapy is a promising treatment for refractory diseases, such as idiopathic osteonecrosis of the femoral head (ONFH), which is difficult to treat [1]. ONFH is a painful disorder and progresses to femoral head collapse, which results in osteoarthritis of the hip joint in young adult [1]. Numerous joint-preserving procedures, such as core decompression (CD) surgery, osteotomy surgery, and physiotherapy, have been performed [2]. Recent development in the clinical application of cell therapy is expected to promote the joint-preserving procedure. The rehabilitation program for this treatment still requires further development. This narrative review aimed to assess the actual state of the rehabilitation program after cell therapy for ONFH. Rehabilitation program was described; and (5) the publication was written in English
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