Abstract
Background: Controversial results concerning the prognostic value of the Tregs cells percentage in peripheral blood of chronic lymphocytic leukemia (CLL) patients have been reported in the previous studies. Materials and Methods: This study aimed to estimate the prognostic relevance of Tregs cells in untreated CLL patients at diagnosis. Results: CLL patients showed significantly higher Tregs percentage and Tregs cell counts as compared that identified in healthy normal controls (p < 0.01 for both). Furthermore, CLL patients with high LDH, β2 microglobulin levels, those positive for CD38% express significantly higher Tregs percentage as compared to those patients with normal LDH, β2 microglobulin levels and negative CD 38%. Also, the percentage of Tregs cells was significantly higher among CLL patients having autoimmune cytopenias. Conclusion: Tregs cells percentage is higher in CLL patients as compared to normal healthy controls and related to advanced stages as well as poor prognostic markers. Tregs manipulation may represent a future strategy for management of CLL patients.
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