Abstract
Purpose: Arthritis is the leading cause of disability in the US. The role of T cells in the immunoregulation of osteoarthritis (OA) is relatively understudied. Suppressor Regulatory T cells (Tregs) are enriched and activated in the inflamed joint but are unable to stop OA progression. To study Tregs in joint homeostasis, a novel tri-culture system of Tregs, synoviocytes, and chondrocytes was developed to model the articular environment. This study tested the hypothesis that an enriched Treg population would mitigate joint inflammation through immunosuppressive functions.
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