Abstract
Esophageal carcinoma is one of the most common malignant tumors and the Kazakh national minority (ethnic) in Xinjiang (northwest of China) has been reported to be one of the highest incidence of Esophageal squamous cell carcinoma (ESCC) in the world. MicroRNA-203 (miR-203) was described as a tumor-suppressive miRNA in several cancers, but little study about the role of miR-203 in Kazakh ESCC. Therefore, we aimed to investigate the role of miR-203 in the occurrence and progression of Kazakh ESCC. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect miR-203 expression, and immunohistochemistry (IHC) was used to examine P63 expression. The expression level of miR-203 in ESCC was significantly lower than that of cancer adjacent normal (CAN) samples (P < 0.05). Whereas the expression level of P63 in ESCC was significantly higher than that of CAN samples (P < 0.05), an inverse association between the expression of P63 and miR-203 was found but was not statistically significant (P > 0.05). These findings suggest that miR-203 is a tumor suppressor gene that plays an important role in inhibiting the occurrence of Kazakh ESCC in Xinjiang, China.
Highlights
Esophageal carcinoma is one of the most common malignant tumors in the world
MiR-203 has been shown to act as a tumor-suppressive micro RNAs (miRNAs), and the down-regulation of miR-203 expression is described in several types of cancer, including lung cancer[13], hepatocellular carcinoma[14], pancreatic cancer[15] and laryngeal squamous cell carcinoma[16]
Few studies about the role of miR-203 in human ex-vivo esophageal squamous cell carcinoma(ESCC) occurrence and progression, and some studies even contradicted with variable results depending on the different ethnic groups
Summary
Esophageal carcinoma is one of the most common malignant tumors in the world. Based on its etiological and pathological characteristics, it is divided into two main forms: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma. The Kazakh national minority (ethnic) in Xinjiang (northwest of China) has been reported to exhibit the highest incidence of ESCC3. MiRNAs are small, non-coding RNA molecules that regulate the expression of protein-coding genes via base pairing to the 3′ -untranslated region (3′ UTR), which affects gene silencing via both translational inhibition and mRNA degradation. MiR-203 has been shown to act as a tumor-suppressive miRNA, and the down-regulation of miR-203 expression is described in several types of cancer, including lung cancer[13], hepatocellular carcinoma[14], pancreatic cancer[15] and laryngeal squamous cell carcinoma[16]. We aimed to investigate whether the aberrant expression of miR-203 exists in Kazakh ESCC. We assessed whether the regulation of miR-203 to P63 is associated with the occurrence and progression of Kazakh ESCC in Xinjiang, China
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